E-commerce websites based on Bitrix Site Manager can be integrated with the CRM. In this case, orders in the e-store will be created as deals in the CRM, and the ordering users will be brought in as contacts. Moreover, sales managers can view the product catalog of the website from the CRM and create orders. These orders will be mirrored in the e-store.
Setup for integration starting from the CRM is done at CRM -> Settings -> Web stores in your intranet.
More details about integration with a Bitrix e-Store can be found here.